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Our research group focusses on the design of electron relays to bridge redox proteins and electrodes for energy conversion and energy saving schemes. Redox enzymes are highly active and selective catalysts for various reactions and are hence attractive for technological applications. We use synthetic chemistry to build redox interfaces on electrode surface to accommodate the target biomolecules with respect to their properties and intended applications. Our main projects involve biosensing, biophotovoltaics, biofuel cells and bioelectrocatalysis.

Biofuel cells
Redox enzymes may play a role as substitute for noble metal in devices for conversion of chemical fuel to electricity. The main issue is the stability of the biocatalysts. We have shown that the electron mediator can be designed to protect the catalyst from various degradation processes to achieve stability over weeks unter constant turn-over conditions for H2 oxidation in biofuel cell1.
We apply our expertise in chemistry and electrochemistry to develop novel strategies to protect sensitive catalysts from the harsh conditions encountered in fuel cells and other technological devices under operation2. To date only materials based on noble metals reached technological applications. In cooperation with W. Schuhmann, O. Rüdiger and W. Lubitz, we designed a redox hydrogel that serves as a protecting matrix for the catalyst3. The concept was successfully demonstrated with a hydrogenase as model for an efficient hydrogen oxidizing catalyst with extreme sensitivity. The hydrogel concept, reported in Nature Chemistry, opens the possibility to integrate a variety of other sensitive biological or artificial catalyst for which the intrinsic stability cannot be further increased. This is a major step toward a novel fuel cell redesign, which may reposition them at the forefront in the race toward global sustainable energy supply.


  1. Plumeré N., Rüdiger O., Alsheikh Oughli A., Williams R., Vivekananthan J., Pöller S., Schuhmann W., Lubitz W. Nature Chemistry, 2014, 6, 822–827. DOI: 10.1038/nchem.2022
  2. Alsheikh Oughli A., Conzuelo F., Winkler M., Happe T., Lubitz W., Schuhmann W., Rüdiger O., Plumeré N. Angew. Chem. Int. Ed., 2015, 54 (42), 12329–12333. DOI: 10.1002/anie.201502776
  3. Fourmond V., Stapf S., Li H., Buesen D., Birrell J., Olaf R.; Lubitz W., Schuhmann W., Plumeré N., Léger C. J. Am. Chem. Soc., 2015, 137, 5494-5505. DOI: 10.1021/jacs.5b01194

Besides organic and inorganic semiconductors, that have reached practical efficiencies and commercial applications, the utilization of photosynthetic material in artificial device to convert light energy is principally demonstrated1. Currently there is a growing recognition of the applicability of the biological machinery of photosynthesis as the active solar cell material. The primary advantage being that these molecular systems have been already optimized for light harvesting and charge separation by over 3 billion years of evolution. In theory the use of photosynthetic proteins may result in biophotovoltaic devices with open circuit voltages in excess of 1 V and non-limiting electron transfer rates1. The utilization of photosynthetic proteins as solar cell material may ultimately provide the cheapest possible photovoltaics devices since these key building blocks can be harvested from organisms such as algae in large scales. Biophotoelectrode designed for photovoltaics may also be applied for chemical fuel production2 and for novel sensing concepts.
To these ends, we design redox hydrogels for highly efficient electrical contacting and stabilization of the natural photosynthetic protein in artificial devices. While early devices yielded only low efficiency3, the fine tuning of electron mediators with redox potentials adjusted to the one of the protein resulted in several order of magnitude improvement in both photocurrents4 and voltages5. Together with our cooperation partners (W. Schuhmann, M. Nowaczyk and M. Rögner), we have shown that electrons provided by photosynthetic proteins can be recovered at artificial conducting materials, even faster than in natural photosynthesis itself4. The possibility to further improve these performances raise the expectation to eventually achieve practical efficiency from biophotovoltaic devices to provide electrical energy both in high tech devices, such as biocompatible photovoltaics in smart contact lenses6, and in low tech, “painted” large scale solar cells which opens new routes for the cost-per-Watt race in electrical energy production7.


  1. Plumeré, N. Nature Na notech. 2012, 7 (10), 616–617.  DOI: 10.1038/nnano.2012.175
  2. Zhao F., Conzuelo F., Hartmann V., Li H., Nowaczyk M. M., Plumeré N., Rögner M., Schuhmann W., J. Phys. Chem. B, 2015, 119 (43), 13726–13731.  DOI: 10.1021/acs.jpcb.5b03511
  3. Kothe, T.; Plumeré, N.; Badura, A.; Nowaczyk, M. M.; Guschin, D. A.; Rögner, M.; Schuhmann, W., Angew. Chem. Int. Ed. 2013, 52 (52), 14233–14236.  DOI: 10.1002/anie.201303671
  4. Kothe T., S. Pöller, F. Zhao, P. Fortgang, M. Rögner, W. Schuhmann, N. Plumeré Chemistry – A European Journal, 2014, 20, 11029–11034. DOI: 10.1002/chem.201402585
  5. Hartmann V.,Kothe T., Pöller S., El-Mohsnawy E., Nowaczyk M. M., Plumeré N., Schuhmann W.,Rögner M., Phys. Chem. Chem. Phys., 2014, 16, 11936-11941.  DOI: 10.1039/C4CP00380B
  6. Ravilious K, Clothes that recharge your laptop – the near-endless possibilities of artificial leaves. Horizon, The research & innovation magazine of the European commission. 16 October 2014
  7. Plumeré et al., Researchers forecast an Ebola vaccine and low-cost solar cells in 2015. Horizon, The research & innovation magazine of the European commission, 5 January 2015
Controlled orientation of redox-active enzymes on electrode surfaces
The direct electron transfer between redox proteins and electrodes is a fundamental issue in bioelectrocatalysis, bioelectronics, biosensors, biofuelcells and nanobiotechnology. The goal of our research is to design functional surfaces on a molecular level to advance our ability to effectively control and direct the electrochemical activity of biomolecules.


We use organic chemistry, molecular biology and electrochemical approaches to build biologic-organic hybrid architectures. We are working on the development of nanosized chelators to achieve the specific recognition and orientation of a redox protein. Our interest is to gain fundamental information on the chelate effect on the supramolecular level. Understanding and adjusting the molecular recognition between the receptor and the guest in combination to designing electron relays to bridge redox enzymes are the key issues to achieve controlled orientation and fast electron transfer. We apply our redox protein immobilization concepts for sensing (nitrate biosensors) and energy conversion applications (bio-photovoltaics and bio-fuel cells).

Figure 1: A receptor-guest assembly between a genetically engineered hydrogenase and a rigid nanosized chelator.


Professorship for Electrobiotechnology

Uferstraße 53
94315 Straubing



Prof. Dr. Nicolas Plumeré
Phone: +49 (0) 9421 187 400



Nadine Ternes
Phone: +49 (0) 9421 187 409